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PARNet

Background

PARNet represents the European Pediatric Anesthesia research Network. All centers running  pediatric anesthesia and interested in being part of large collaborative projects are welcome to be part of the network. For this reason multiple projects will be performed under the PARNet umbrella.  

Chair

Prof. Nicola Disma, IRCCS Istituto Giannina Gaslini, Genova, Italy

Vice-Chair

Prof. Maren Kleine-Brueggeney, U German Heart Center Berlin and Charité – Universitaetsmedizin, Berlin, Germany

Steering committee members

Arash Afshari – Rigshospitalet, Denmark; Karin Becke – Cnopf Children’s Hospital, Germany; Nicola Clausen – University Hospital Odense, Denmark; Margaret Ekstein – Telaviv Hospital, Israel; Peter Frykholm – University of Uppsala, Sweden; Patricio González – La Paz Children’s Hospital, Spain; Walid Habre – University of Geneva, Switzerland; Thomas Riva -University of Bern, Switzerland; Carolina Romero – University Hospital, Spain; Francis Veyckemans – Hôpital Jeanne de Flandre, France; Britta von Ungern Sternberg – University of Western Australia, Australia; Vinicius Quintao – Universidade de São Paulo, Hospital das Clínicas, Faculdade de Medicina, Brazil; Anna Camporesi – Buzzi Children’s Hospital, Milan, Italy; Jean-Philippe Salaün – CHU Caen Normandie, Caen, France; Robert Frithiof – Uppsala University, Sweden; Jonny Kenth –  Royal Manchester Children’s Hospital, Manchester, UK; Sonia Garcés-Sánchez – Hospital Universitari i Politècnic La Fe, Valencia (Spain)

Collaboration

The PARNet Research Group is part of the ESAIC-ESPA collaboration which aims to bring together networks from both the societies in order to develop and run research projects.

espa

The PARNet Research Group is part of the ESAIC-APAGBI collaboration which aims to bring together networks from societies in the UK and Europe.

Ongoing Projects

CRICKET (Critical Events during tracheal intubation in kids)

A prospective observational study looking at major complications occurring during tracheal intubation in children undergoing general anaesthesia. Children from 0 to 16 years requiring tracheal intubation for general anaesthesia performed by the anaesthesia team are eligible for the study.

The aim is to include 100,000 patients within a period of 3 consecutive months, in 500 centres spread in all continents.

Status:

• 50,000 patients have been enrolled from 380 centres in five continents

• Recruitment is completed

– Data cleaning will start soon and the team is aiming for statistical analysis by the end of 2026

For further information contact the study coordinator at: CRICKET@insel.ch

Explore the website at: www.cricketstudy.eu

Principal investigators: Prof. Nicola Disma and Prof. Thomas Riva

EUROFast (European Preoperative Fasting Audit)

A prospective observational study with the primary aim to determine the safety of reducing the required fasting time for clear fluids to at least one hour before elective procedures (as recommended in the ESAIC guideline). Secondary aims are to investigate risk factors for aspiration and real fasting times associated with registered events.

This project has been successfully completed with the inclusion of 307,000 patients.

Principal investigators: Dr/Prof Peter Frykholm

Link to publication

The Big Apple Study

International observational study on the current practice of ventilation strategies in children undergoing general anaesthesia and the occurrence post-operative pulmonary complications. The study includes a 14-day inclusion period in each centre and is complemented by a pilot study taking place in the Amsterdam UMC. The recruitment is completed, with around 3,000 patients into the database. The Big Apple team is now analysing data for publication.

For further information contact: bigapple@amsterdamumc.nl

Explore the website at: https://icuresearch.nl/studies/big-apple

Principal Investigator: Dr/Prof David van Meenen

PORPOISE Study

Focuses on planning physiological monitoring in the operating room and predicting outcomes using infra-red sensors. It is a feasibility study involving 500 children from 3-6 centers.

The ultimate aim is for this study to lead into a randomized controlled trial (RCT).

The PORPOISE Feasibility study is running smoothly. Inclusion has started at all five sites (Perth, Sao Paolo, Brussels, Genova and Uppsala) and recruitment will finish soon. 

Principal Investigator: Dr/Prof Peter Frykholm

New Proposals

POAKIDS (A European Multicentre Prospective Study of Postoperative Acute Kidney Injury in Hospitalized Paediatric Patients)

European multicentre prospective study focusing on postoperative acute AKI in children undergoing non-cardiac surgery. Secondary endpoint includes markers from urine.

Recruitment started but there is opportunity for participation, if centres are interested.

Principal Investigator: Prof. Robert Frithiof

SUSTAIN-EUROPE

The SUSTAIN-EUROPE Trial aims to describe the current anaesthesia practices in paediatric and adult patients undergoing surgery with anaesthesia care across Europe (including inhalational and intravenous general anaesthesia, regional anaesthesia, sedation, and combinations thereof) in a large-scale, prospective, observational study. By providing information on the status-quo we seek to identify potential areas for improvement of sustainable practices that can be addressed in future studies. 

The team is looking for national coordinators. If you are interested contact Linda Gruber at sustain-europe@esaic.org

Data collection will be facilitated by a dedicated app and will last one week (= 5 consecutive days). For more information, please visit our website 

BELUGA

The aim of BELUGA study is to compare the overall combined rate of postoperative respiratory adverse events in children at emergence and in PACU following extubation either 

(1)directly at end of surgery or (2)after exchange of the ETT airway to a SGA followed by awake removal of SGA. Sample size is 1,400 patients, 700 per group. 

PI: Prof. Britta von Ungern Sternberg – University of Western Australia, Australia

ACORN (Anaesthesia Consumer Research Network)

ACORN is a multi centre survey aimed at identifying research priorities in paediatric anaesthesia. Through an electronic survey, children will be requested to provide their ideas for future of research in paediatric anaesthesia. The survey will be conducted in multiple languages.  

PI: Prof. Britta von Ungern Sternberg – University of Western Australia, Australia