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The ESAIC is dedicated to supporting professionals in anaesthesiology and intensive care by serving as the hub for development and dissemination of valuable educational, scientific, research, and networking resources.



The ESAIC hosts the Euroanaesthesia and Focus Meeting congresses that serve as platforms for cutting-edge science and innovation in the field. These events bring together experts, foster networking, and facilitate knowledge exchange in anaesthesiology, intensive care, pain management, and perioperative medicine. Euroanaesthesia is one of the world’s largest and most influential scientific congresses for anaesthesia professionals. Held annually throughout Europe, our congress is a contemporary event geared towards education, knowledge exchange and innovation in anaesthesia, intensive care, pain and perioperative medicine, as well as a platform for immense international visibility for scientific research.


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The ESAIC's mission is to foster and provide exceptional training and educational opportunities. The ESAIC ensures the provision of robust and standardised examination and certification systems to support the professional development of anaesthesiologists and to ensure outstanding future doctors in the field of anaesthesiology and intensive care.



The ESAIC aims to advance patient outcomes and contribute to the progress of anaesthesiology and intensive care evidence-based practice through research. The ESAIC Clinical Trial Network (CTN), the Academic Contract Research Organisation (A-CRO), the Research Groups and Grants all contribute to the knowledge and clinical advances in the peri-operative setting.

Learn more about the ESAIC Clinical Trial Network (CTN) and the associated studies.


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The ESAIC is actively involved as a consortium member in numerous EU funded projects. Together with healthcare leaders and practitioners, the ESAIC's involvement as an EU project partner is another way that it is improving patient outcomes and ensuring the best care for every patient.


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The ESAIC aims to promote the professional role of anaesthesiologists and intensive care physicians and enhance perioperative patient outcomes by focusing on quality of care and patient safety strategies. The Society is committed to implementing the Helsinki Declaration and leading patient safety projects.



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The ESAIC works in collaboration with industry, national societies, and specialist societies to promote advancements in anaesthesia and intensive care. The Industry Partnership offers visibility and engagement opportunities for industry participants with ESAIC members, facilitating understanding of specific needs in anaesthesiology and in intensive care. This partnership provides resources for education and avenues for collaborative projects enhancing science, education, and patient safety. The Specialist Societies contribute to high-quality educational opportunities for European anaesthesiologists and intensivists, fostering discussion and sharing, while the National Societies, through NASC, maintain standards, promote events and courses, and facilitate connections. All partnerships collectively drive dialogue, learning, and growth in the anaesthesiology and intensive care sector.



Guidelines play a crucial role in delivering evidence-based recommendations to healthcare professionals. Within the fields of anaesthesia and intensive care, guidelines are instrumental in standardizing clinical practices and enhancing patient outcomes. For many years, the ESAIC has served as a pivotal platform for facilitating continuous advancements, improving care standards and harmonising clinical management practices across Europe.



With over 40 years of publication history, the EJA (European Journal of Anaesthesiology) has established itself as a highly respected and influential journal in its field. It covers a wide range of topics related to anaesthesiology and intensive care medicine, including perioperative medicine, pain management, critical care, resuscitation, and patient safety.



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Link to trial website

Link to Publication


Accepted for Publication: May 17, 2019.

Published Online: June 3, 2019.


Postoperative respiratory failure, particularly after surgery under general anaesthesia, adds to the morbidity and mortality of surgical patients. Anesthesiologists inconsistently use positive end-expiratory pressure (PEEP) and recruitment manoeuvres in the hope that this may improve oxygenation and protect against postoperative pulmonary complications (PPCs), especially in obese patients. While it is uncertain whether a strategy that uses higher levels of PEEP with recruitment manoeuvres truly prevents PPCs in these patients, use of higher levels of PEEP with recruitment manoeuvres could compromise intraoperative hemodynamics. 

The aims of the PROBESE study are:

This study compared the effects of higher levels of PEEP with recruitment manoeuvres versus lower levels of PEEP without recruitment manoeuvres during general anaesthesia for surgery on pulmonary and extrapulmonary outcome measures in obese patients with BMI ≥ 35 kg/m2 at intermediate-to-high risk for PPCs. 


Among 2013 adults who were randomized, 1976 (98.2%) completed the trial (mean age, 48.8 years; 1381 [69.9%] women; 1778 [90.1%] underwent abdominal operations). In the intention-to-treat analysis, the primary outcome occurred in 211 of 989 patients (21.3%) in the high level of PEEP group compared with 233 of 987 patients (23.6%) in the low level of PEEP group (difference, −2.3%[95%CI, −5.9%to 1.4%]; risk ratio, 0.93 [95%CI, 0.83 to 1.04]; P = .23). Among the 9 prespecified secondary outcomes, 6 were not significantly different between the high and low level of PEEP groups, and 3 were significantly different, including fewer patients with hypoxemia (5.0%in the high level of PEEP group vs 13.6%in the low level of PEEP group; difference, −8.6%[95%CI, −11.1% to 6.1%]; P < .001). 

List of chief Investigator and Steering Committee Members

Chief Investigator Gama de Abreu, Marcelo  Department of Anesthesiology and Intensive Care, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany (mgabreu@uniklinikum-dresden.de
Bluth, Thomas Department of Anesthesiology and Intensive Care, Pulmonary Engineering Group, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany 
Bobek, Ilona Aneszteziológiai és Intenzív Terápiás Klinika, Semmelweis Egyetem, Hungary 
Canet, Jaume University Hospital Germans Trias i Pujol, ICS, UAB, Spain 
Cinnella, Gilda Department of Anesthesiology and Intensive Care Medicine, University of Foggia, Italy 
de Baerdemaeker, Luc Ghent University Hospital, Ghent, Belgium. Corneel Heymanslaan 10, 9000 Gent, Belgium 
Gregoretti, Cesare Department of Anesthesiology, Città della Salute e della Scienza, Turin, Italy 
Hedenstierna, Göran Department of Medical Sciences, Section of Clinical Physiology, University Hospital, Uppsala, Sweden 
Hemmes, Sabrine Amsterdam UMC, University of Amsterdam, Department of Anesthesiology, Meibergdreef 9, Amsterdam, The Netherlands 
Hiesmayr, Michael Division Cardiac, Thoracic, Vascular Anesthesia and Intensive Care, Medical University, Vienna, Austria 
Hollmann, Markus W. Amsterdam UMC, University of Amsterdam, Department of Anesthesiology, Meibergdreef 9, Amsterdam, The Netherlands 
Jaber, Samir Department of Critical Care Medicine and Anesthesiology (SAR B), Saint Eloi University Hospital, Montpellier, France 
Laffey, John Department of Anesthesiology, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada 
Licker, Marc-Joseph Hôpitaux Universitaires de Genève, Département APSI, service d’anesthésiologie; Faculty of Medicine, University of Geneva, Switzerland 
Markstaller, Klaus Department of Anaesthesia,Critical Care and Pain Medicine, Medical University Vienna, Austria 
Matot, Idit Division of Anesthesia, Pain and Critical Care, Tel-Aviv Medical Center affiliated with Sackler Medical School, Tel Aviv University, Tel Aviv, Israel 
Mills, Gary H Operating Services, Critical Care and Anaesthesia (OSCCA), Sheffield Teaching Hospitals and University of Sheffield, United Kingdom 
Mulier, Jan Paul Department of Anesthesiology, AZ Sint Jan Brugge-Oostende AV, Belgium 
Pelosi, Paolo Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate – DISC – Università degli Studi di Genova – Genova – Italy and Anestesia e Terapia Intensiva – IRCCS Policlinico San Martino – Genova – Italy 
Putensen, Christian Department of Anaesthesiology and Intensive Care Medicine, University Hospital of Bonn, Bonn, Germany 
Rossaint, Rolf Department of Anesthesiology, Medical Faculty, RWTH Aachen University, Aachen, Germany 
Schmitt, Jochen Center for Evidence-based Healthcare, University Hospital Dresden, Germany 
Schultz, Marcus J. Amsterdam UMC, University of Amsterdam, Department of Anesthesiology, Meibergdreef 9, Amsterdam, The Netherlands 
Senturk, Mert Istanbul University, Istanbul Faculty of Medicine, Turkey 
Serpa Neto, Ary Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, Brazil 
Severgnini, Paolo Universita’ della’insubria – Dipartimento di Anestesia – Azienda Ospedaliera asst Settelaghi Ospedale di Circolo e Fondazione Macchii – 21100 Varese – Italy 
Sprung, Juraj Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA 
Vidal Melo, Marcos Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA 
Wrigge, Hermann Department of Anaesthesiology and Intensive Care Medicine, University of Leipzig, Leipzig, Germany and Department of Anaesthesiology, Intensive Care and Emergency Medicine, Pain Therapy; Bergmannstrost Hospital Halle, Halle, Germany 


The study is sponsored by a grant of the European Society of Anaesthesiology Clinical Trial Network (ESAIC CTN). 

Contact email for more info => research@esaic.org