SQUEEZE Study
An explanation by the Chief Investigators Dr. Ib Jammer and Dr. Ben Creagh-Brown
Latest news
- SQUEEZE study Protocol has been published in Perioperative Medicine.
- Data cleaning was finalised in February 2024. The Chief Investigators will then work on the statistical analysis and manuscript writing.
Chief Investigators
- Dr. Ib JAMMER (Haukeland University Hospital – Bergen, Norway)
- Dr. Ben Creagh-Brown (Royal Surrey County Hospital NHS Foundation Trust – Guildford, United Kingdom)
Steering Committee
Lui Forni (UK), Ramani Moonesinghe (UK), Hannah Wunsch (Canada) and Peter Martin (UK).
The Study is entirely sponsored by a grant from the European Society of Anaesthesiology and Intensive Care Clinical Trial Network (ESAIC CTN). The aim of the European Society of Anaesthesiology and Intensive Care Clinical Trial Network is to provide an infrastructure for clinical research in the fields of Anaesthesia, Pain, Intensive Care and Emergency Medicine by transnational European collaborative studies.
Objective
- To evaluate the proportion of non-cardiac surgical patients receiving postoperative vasopressors.
- To evaluate the characteristics of patients, surgery and anaesthesia that lead to postoperative vasopressor use.
- To evaluate the incidence of organ injury in patients who receive postoperative vasopressors
- To evaluate the variability in postoperative vasopressor use across healthcare environments.
Medical Problem
In the era of goal-directed fluid therapy and increasing popularity of restrictive fluid resuscitation, patients may be receiving less intravenous fluid and receiving more infused vasopressors to maintain adequate blood pressure.
There is anecdotal evidence of substantial variation in the management of post-operative hypotension between centres, countries and continents. The variation is in assessment (cardiac output and invasive monitoring), environment (post-operative care units, high-dependency units, ICUs) and management (use and choice of fluids and vasopressors/inotropes).
In critically ill populations, receipt of infused vasopressors is associated with organ dysfunction, it has not been established if this relationship is true in postoperative populations.
Outcome Measures
- Incidence of vasopressor use and elucidation of risk factors
- Postoperative organ dysfunction in patients receiving infused vasopressors.
- Timeline
- The study selected by ESAIC Research Committee: April 2018
- Call for centres: Closed
- Recruitment ended 31st June 2023
Endorsements
Support
SQUEEZE Study is supported by :
